8-Aminospiro[3.5]non-7-EN-6-one → 4-Hydroxy-7,7-dimethyl-2',3',5',6',7,8-hexahydro-3H-spiro[furo[3,4-c]quinoline-1,4'-pyran]-3,9(6H)-dione
Reaction equation
[O:1]=[C:2]1[C:6]([C:7]([O-:9])=O)=[CH:5][C:4]2([CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[O:3]1.[NH2:15][C:16]1[CH2:24][C:20]2([CH2:23]C[CH2:21]2)[CH2:19][C:18](=[O:25])[CH:17]=1>>[OH:9][C:7]1[C:6]2[C:2](=[O:1])[O:3][C:4]3([CH2:14][CH2:13][O:12][CH2:11][CH2:10]3)[C:5]=2[C:17]2[C:18](=[O:25])[CH2:19][C:20]([CH3:23])([CH3:21])[CH2:24][C:16]=2[N:15]=1Participants
3
Procedure
Obtained by starting from 2-oxo-1,8-dioxaspiro[4.5]dec-3-ene-3-carboxylate and 8-aminospiro[3.5]non-7-en-6-one.
Workup
- customObtained
Sources & evidence
- ORD record
- ord-bb39378759ae495ba0f365f97e5e9bb8
- Source dataset
- uspto-grants-2015_05
- Patent number
- US09029544B2
Reaction notes
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