Methyl iodide → HCID 66761672, compound

Participants

Reaction Conditions

Reaction Steps

25 mg 2-((3R,9S)-9-(tert-butyldimethylsilyloxy)-7,7-dimethyl-3-(4-(trifluoromethyl)phenyl)-2′,3′,5′,6,6′,7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4′-pyran]-4-yl)propan-2-ol are dissolved in 1 ml N,N-dimethylformamide, cooled to 0° C., treated with 3 mg sodium hydride (60% in mineral oil) and stirred for 1 minute. Then 5 μl methyliodide are added and the mixture is stirred for 4 hours at room temperature. The mixture is diluted with diethylether, washed with saturated aqueous ammonium chloride and dried with magnesium sulphate.

Provenance & Evidence