1-(2-Isopropyl-5-methoxyphenyl)thiourea → (1Z)-1-[3-(5-methoxy-2-propan-2-ylphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-[2-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]butyl]urea

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Isopropyl-5-methoxyphenyl)thiourea	HCID 90404099	—
Reactant	3-(4-(1-(4-(trifluoromethoxy)phenyl)-1 H-1,2,4-triazol-3-yl)phenyl)pentanoyl azide 3-(4-(1-isocyanatobutan-2-yl)phenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole	HCID 90418760	—
Product	(1Z)-1-[3-(5-methoxy-2-propan-2-ylphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-[2-[4-[1-[4-(trifluoromethoxy)phenyl]-1,2,4-triazol-3-yl]phenyl]butyl]urea	HCID 90404891	—

Reaction Steps

The title compound was prepared from 3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)pentanoyl azide/3-(4-(1-isocyanatobutan-2-yl)phenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole (C42a) and 1-(2-isopropyl-5-methoxyphenyl)thiourea (CA40) and isolated as a brown foam (0.091 g, 47%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09029560B2
Source dataset	uspto-grants-2015_05
ORD ID	ord-2bc701669dcf4e26b9150b3d820280d7
Source note	uspto-grants-2015_05