Dicyclohexylcarbodiimide → (S)-2-(1-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)ethyl)isoindoline-1,3-dione

참여 물질

역할	이름	HCID	투입량
반응물	Dicyclohexylcarbodiimide	HCID 10868	—
반응물	Pht-Ala-OH	HCID 720644	—
반응물	3-chloro-N'-hydroxybenzenecarboximidamide	HCID 9582834	—
생성물	(S)-2-(1-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)ethyl)isoindoline-1,3-dione	HCID 90414565	—

반응 조건

온도	100 °C

반응 단계

To a stirred solution of (Z)-3-chloro-N′-hydroxybenzimidamide (500 mg, 2.93 mmol) and (S)-2-(1,3-dioxoisoindolin-2-yl)propanoic acid (642 mg, 2.93 mmol) was added N,N′-methanediylidenedicyclohexanamine (1.1 eq, 665 mg, 3.22 mmol) and allowed to reflux at 100° C. for 12 hours. Concentrate in vacuo, dilute w/EtOAc, filter washing w/EtOAc, wash w/water, brine, concentrate in vacuo. Flash column chromatography (silica, 40 g) eluting w/0-10% EtOAc/DCM afforded 300 mg. HRMS m/z 353.0567

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09434719B2
출처 데이터셋	uspto-grants-2016_09
ORD ID	ord-7c8cb4017f714552a7782879abcbc5bb
출처 메모	uspto-grants-2016_09