HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4-Difluoropiperidine hydrochloride → (S)-tert-butyl 1-(4-((4,4-difluoropiperidin-1-yl)methyl)-3-fluorophenyl)ethylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4-Difluoropiperidine hydrochloride | HCID 2758351 | — |
| Reactant | Aluminum | HCID 5359268 | — |
| Reactant | (S)-tert-butyl 1-(3-fluoro-4-formylphenyl)ethylcarbamate | HCID 86730149 | — |
| Product | (S)-tert-butyl 1-(4-((4,4-difluoropiperidin-1-yl)methyl)-3-fluorophenyl)ethylcarbamate | HCID 90415713 | — |
Reaction Steps
Following the procedure for intermediate 111: Title compound was prepared from (S)-tert-butyl 1-(3-fluoro-4-formylphenyl)ethylcarbamate and 4,4-difluoropiperidine hydrochloride as a white solid. LCMS tR=1.63 min; MS m/z 371.5 (M−H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434719B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-3f40672f04234437b94cc209b747090f |
| Source note | uspto-grants-2016_09 |