HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 57398Generated: October 25, 2026
Methylhydrazine → HCID 28350836, compound
https://huagongshe.com/reaction/57398
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | (S)-2-(1-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)ethyl)isoindoline-1,3-dione | HCID 90414565 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 28350836 | HCID 28350836 | 79% |
Reaction Steps
To a stirred solution of (S)-2-(1-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)ethyl)isoindoline-1,3-dione (100 mg, 0.283 mmol) in ethanol (5 ml) was added methylhydrazine (16 μL, 0.311 mmol). Stir for 13 hours at 80° C. Concentrate in vacuo. Flash column chromatography (silica, 40 g) eluting with dichloromethane afforded 50 mg of desired product. HRMS m/z 224.4 (M+H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09434719B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-c0484a65662f4d4782b8e2f99ba49d47 |
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| Source note | uspto-grants-2016_09 |
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