反应详情

温度

-20 °C

A solution of morpholine (1.5 mL, 17.05 mmol) in ethanol (25 mL) was added to a cooled (−20° C.) solution of 2,4,6-trichloro-5-fluoropyrimidine (3.00 g, 14.93 mmol) in ethanol (150 mL) and the resulting mixture was stirred at −20° C. for 30 minutes and at ambient temperature for 3 hours. The solvent was evaporated under reduced pressure and the residue was partitioned between water and methylene chloride. The organic layer was separated, dried and the solvent evaporated under reduced pressure. The resulting white solid was triturated with ethanol, then filtered and dried to give the title compound (2.0 g, 53%).

1. customThe solvent was evaporated under reduced pressure
2. customthe residue was partitioned between water and methylene chloride
3. customThe organic layer was separated
4. customdried
5. customthe solvent evaporated under reduced pressure
6. customThe resulting white solid was triturated with ethanol
7. filtrationfiltered
8. customdried