Sodium Iodide → HCID 71245107, compound

Participants

Reaction Conditions

Reaction Steps

Trimethylsilyl chloride (0.20 mL, 1.58 mmol) and sodium iodide (235 mg, 1.57 mmol) were added to a stirred solution of (S)—N4-(1-(5-fluoropyridin-2-yl)ethyl)-N2-(2-methoxypyridin-3-yl)-5-methylpyrimidine-2,4-diamine (Preparation 2b, 185 mg, 0.52 mmol) in acetonitrile (5 mL) and the mixture was stirred and heated at 80° C. for 45 min. After cooling to ambient temperature, the mixture was concentrated and treated with saturated aqueous sodium thiosulphate solution. After stirring for 10 minutes, the precipitate was filtered, washed with water and diethyl ether and dried to give the title compound (179 mg, 100%) as a solid.

Provenance & Evidence