Hydrogen Bromide → HCID 71245087, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)-5-chloro-N4-(1-(5-fluoropyridin-2-yl)ethyl)-N2-(2-methoxypyridin-3-yl) pyrimidine-2,4-diamine (Preparation 3b, 0.184 g, 0.49 mmol) and 48% aqueous hydrogen bromide solution (1.6 mL) was heated to 100° C. for 3 hours. The solvent was evaporated under reduced pressure and the residue was treated with a saturated aqueous solution of potassium carbonate and then extracted with ethyl acetate (×3). The combined organic extracts were dried (Na2SO4) and the solvent evaporated to yield the title compound (0.154 g, 91%) as a white solid.

Provenance & Evidence