Hydrogen Bromide → HCID 71498512, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)—N4-(1-(5-fluoropyridin-2-yl)ethyl)-5-methoxy-N2-(2-methoxypyridin-3-yl)pyrimidine-2,4-diamine (Preparation 4b, 0.200 g, 0.54 mmol) and 48% aqueous hydrogen bromide solution (1.8 mL) was stirred and heated to 100° C. overnight. The solvent was evaporated under reduced pressure and the residue was treated with a saturated aqueous solution of potassium carbonate and then extracted with ethyl acetate (×3). Concentrated aqueous hydrogen chloride solution was then added to the aqueous solution until an acidic pH was reached and the white solid that formed was filtered and dried to give the title compound (0.047 g, 25%).

Provenance & Evidence