HCID 71245120, compound → HCID 71245060, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N′-(2-methoxypyridin-3-yl) pyrazine-2,6-diamine (Preparation 12b, 100 mg, 0.29 mmol) in 48% aqueous hydrogen bromide solution (1 mL) was stirred and heated at 100° C. for 3 hours. After cooling to ambient temperature, the solvent was evaporated under reduced pressure. The residue was treated with acetonitrile and the solid that formed was filtered and dried to give the hydrobromide salt of the title compound (98 mg, 68%) as a yellow solid.

Provenance & Evidence