HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → M-Cresol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | 2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) | HCID 22230 | — |
| Reactant | HCID 22237896 | HCID 22237896 | — |
| Catalyst | Zinc Acetate | HCID 11192 | — |
| Solvent | Glycerol | HCID 753 | — |
| Product | M-Cresol | HCID 342 | — |
| Product | Phenol | HCID 996 | — |
| Product | Sodium Chloride | HCID 5234 | — |
| Product | 2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) | HCID 22230 | — |
Reaction Steps
An aqueous solution (Stock solution I) of phenol, m-cresol, glycerol and NaCl was prepared together with an aqueous solution (Stock solution II) of LysB29Nε-hexadecandioyl-γ-Glu desB30 human insulin. An aqueous solution (Stock solution III) of citrate (citric acid, monohydrate) was prepared and pH was adjusted to 7.4 using diluted HCl/NaOH. A fraction of Stock solution I was mixed with variable amounts of Stock solution III and a fraction of Stock solution II was added and pH was adjusted to about 7.5. An aqueous 10 mM zinc acetate solution was added in six equal portions, pH was adjusted to 7.4 using diluted HCl/NaOH and the solution was filtered through a 0.22 μm sterile filter.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034818B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-06313db79fb4422c9b1faa1c40d339ad |
| Source note | uspto-grants-2015_05 |