2-Chloro-N,N-dimethylethylamine → HCID 74387732, compound

HRID 574067Notes

Reaction equation

HRID 574067 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:27]=[CH:26][C:12]([O:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][C:15]=3[C:22]([F:25])([F:24])[F:23])=[C:11]([F:28])[CH:10]=2)[S:3]1.Cl[CH2:30][CH2:31][N:32]([CH3:34])[CH3:33]>>[CH3:33][N:32]([CH3:34])[CH2:31][CH2:30][N:6]1[C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:27]=[CH:26][C:12]([O:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][C:15]=3[C:22]([F:25])([F:23])[F:24])=[C:11]([F:28])[CH:10]=2)[S:3][C:2]1=[O:1]

Participants

3

Reactant 2

HCID 79012-Chloro-N,N-dimethylethylamineHCID 74387388HCID 74387388, compound

Product 1

HCID 74387732HCID 74387732, compound

Procedure

The title compound was prepared using 4-[4-(2,4-Dioxo-thiazolidin-5-ylidenemethyl)-2-fluoro-phenoxy]-3-trifluoromethyl-benzonitrile and (2-Chloro-ethyl)-dimethyl-amine as described in Example 1. 1H NMR (400 Hz, CDCl3) δ 7.95 (s, 1H), 7.76 (s, 1H), 7.69 (dd, 1H), 7.27 (m, 3H), 6.84 (d, 1H), 3.91 (t, 2H), 2.76 (bt, 2H), 2.40 (s, 6H); LC/MS (m/z) [M+1]+ 480.1 (calculated for C22H18F4N3O3S, 480.45).

Sources & evidence

ORD record
ord-f487017591104657ad043486ce422d74
Source dataset
uspto-grants-2015_05
Patent number
US09034852B2

Reaction notes

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