4-(2-Chloroethyl)morpholine → HCID 74387730, compound

HRID 574068Notes

Reaction equation

HRID 574068 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:27]=[CH:26][C:12]([O:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][C:15]=3[C:22]([F:25])([F:24])[F:23])=[C:11]([F:28])[CH:10]=2)[S:3]1.Cl[CH2:30][CH2:31][N:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>>[F:28][C:11]1[CH:10]=[C:9]([CH:8]=[C:4]2[S:3][C:2](=[O:1])[N:6]([CH2:30][CH2:31][N:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)[C:5]2=[O:7])[CH:27]=[CH:26][C:12]=1[O:13][C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][C:15]=1[C:22]([F:25])([F:23])[F:24]

Participants

3

Reactant 2

HCID 767274-(2-Chloroethyl)morpholineHCID 74387388HCID 74387388, compound

Product 1

HCID 74387730HCID 74387730, compound

Procedure

The title compound was prepared using 4-[4-(2,4-Dioxo-thiazolidin-5-ylidenemethyl)-2-fluoro-phenoxy]-3-trifluoromethyl-benzonitrile and 4-(2-Chloro-ethyl)-morpholine as described in Example 1. 1H NMR (400 Hz, CDCl3) δ 8.01 (s, 1H), 7.83 (s, 1H), 7.74 (dd, 1H), 7.34 (m, 3H), 6.91 (d, 1H), 3.92 (t, 2H), 3.69 (bt, 2H), 2.69 (bt, 2H), 2.57 (bs, 2H); LC/MS (m/z) [M+1]+ 522.2 (calculated for C24H20F4N3O4S, 522.49).

Sources & evidence

ORD record
ord-14bd93a505074f988246b9cc99d9a4b5
Source dataset
uspto-grants-2015_05
Patent number
US09034852B2

Reaction notes

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