2-Iodobenzylic alcohol → 2-Iodobenzaldehyde

HRID 574073Notes

Reaction equation

HRID 574073 reaction equation
[I:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>ClCCl.[O-2].[Mn+2]>[I:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

Participants

4

Reactant 1

HCID 1076292-Iodobenzylic alcohol

Product 1

HCID 6434392-IodobenzaldehydeYield 91%

Reagents, catalysts & solvents 2

HCID 160959Manganese oxideCatalystHCID 6344DichloromethaneSolvent

Procedure

In a flask, 2-iodobenzyl alcohol (4 g, 17.09 mmol) was dissolved in dichloromethane (MC, 85 ml), and then, manganese oxide (MnO2, 14.86 g, 170.92 mmol) was added thereto. The obtained reaction product was stirred under the reflux condition. When the reaction was completed, the obtained reaction product was cooled to the room temperature, and then, fiteated and concentrated using celite, to obtain the title compound (3.6 g, yield 91%).

Workup

  1. customThe obtained reaction product
  2. customthe obtained reaction product
  3. concentrationfiteated and concentrated

Sources & evidence

ORD record
ord-dd8dd52986c64ec6929d1a519b9b99e3
Source dataset
uspto-grants-2015_05
Patent number
US09034848B2

Reaction notes

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