Sodium Methoxide → HCID 86669364, compound

Participants

Reaction Steps

To a solution of (4-bromo-2-fluoro-phenyl)-(2,3,5-trifluoro-6-nitro-phenyl)-amine (Intermediate 13, 1.5 g, 4.1 mmol) in THF (10 mL) was dropwise added NaOMe solution [prepared by dissolving Na metal (100 mg, 4.1 mmol) in methanol (10 mL)] at −78° C. After complete addition, the reaction mixture was warmed to room temperature and stirred for 1 h. The progress of reaction was monitored by TLC. After completion, the reaction mixture was concentrated under reduced pressure and residue obtained was purified by flash column chromatography to yield (4-bromo-2-fluoro-phenyl)-(2,5-difluoro-3-methoxy-6-nitro-phenyl)-amine as a yellow solid (912 mg).

Provenance & Evidence