反应详情

1.50 g of the product of Example 172 was dissolved in 10 ml of chloroform, to the solution was added 3 ml of methyl iodide at a room temperature, and the mixture was stirred for 40 minutes. Excess methyl iodide was immediately evaporated off under a reduced pressure, and resulting residue was purified on a silica gel column (silica gel 50 g, eluant: 5% methanol in chloroform), to obtain 720 mg of the title compound in a colorless amorphous form.

1. customExcess methyl iodide was immediately evaporated off under a reduced pressure
2. customresulting residue
3. customwas purified on a silica gel column (silica gel 50 g, eluant: 5% methanol in chloroform)