HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → 3-({3-[2-(4-Cyano-phenylamino)-acetylamino]-4-methylamino-benzoyl}-phenyl-amino)-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | N-(4-Cyanophenyl)glycine | HCID 817965 | — |
| Reactant | 3-[(3-Amino-4-methylamino-benzoyl)-phenyl-amino]propionic acid methyl ester | HCID 18412336 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-({3-[2-(4-Cyano-phenylamino)-acetylamino]-4-methylamino-benzoyl}-phenyl-amino)-propionic acid methyl ester | HCID 66706328 | — |
Reaction Steps
The product of 1b (23.2 mmol) and N-(4-cyano-phenyl)-glycine (23.2 mmol) were coupled with CDI (23.2 mmol) in dry THF at room temperature. After completion of the reaction the mixture was evaporated to dryness and the crude product was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034822B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-652de8d03ddc42a78150111980eaa109 |
| Source note | uspto-grants-2015_05 |