反应详情

The 3-(hydroxymethyl)-β-carboline was added to an excess (3 grams) of thionyl chloride and the mixture was refluxed for 1 hour. The excess thionyl chloride was then evaporated and the obtained residue was crystallized from hexane. 2.5 grams of 3-(chloromethyl)-β-carboline was obtained.

1. temperaturethe mixture was refluxed for 1 hour
2. customThe excess thionyl chloride was then evaporated
3. customthe obtained residue was crystallized from hexane