Lithium Hydroxide → HCID 59536933, compound

Participants

Reaction Steps

The enantiomerically pure ester of Example 6A (1.6 g, 4.21 mmol) was dissolved in 77 ml of methanol, and 17 ml of a 1M solution of lithium hydroxide in water were added. The mixture was stirred at RT for 1 h and then concentrated on a rotary evaporator. The residue was diluted with 100 ml of water and acidified to pH 1-2 with 1N of hydrochloric acid. The precipitated product was filtered off, washed successively with water and cyclohexane and sucked dry. Further drying under HV gave the title compound (1.1 g, 71% of theory).

Provenance & Evidence