Hydrochloric Acid → HCID 56932661, compound

Participants

Reaction Steps

64 mg (0.106 mmol) of the compound of Example 5 were dissolved in 3 ml of methanol, and 422 μl of a 1M aqueous lithium hydroxide solution (0.42 mmol) were added. The mixture was stirred at RT overnight. Since the reaction was very slow, another 210 μl (0.21 mmol) of a 1M sodium hydroxide solution were added and the mixture was stirred at RT for another 5 days. By addition of 1N hydrochloric acid, the mixture was adjusted to pH 2, diluted with a little DMSO and separated by preparative HPLC [Method 6]. This gave 37 mg (61% of theory) of the title compound.

Provenance & Evidence