HRID574158

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)Cn1nc(-c2ccc(Cl)cc2)n(/C=C/C(F)(F)F)c1=O

HCID59536906

未命名化合物

结构：CC(C)(NC(=O)C(N)c1ccccc1C(F)(F)F)C(N)=O.Cl

HCID89780485

未命名化合物

PRODUCTS

生成物

结构：CC(C)(NC(=O)C(NC(=O)Cn1nc(-c2ccc(Cl)cc2)n(/C=C/C(F)(F)F)c1=O)c1ccccc1C(F)(F)F)C(N)=O

HCID56932706

未命名化合物

PROCEDURE

实验过程

Analogously to Example 1, 25 mg (72 μmol) of the compound of Example 11A and 29 mg (79 μmol) of the compound of Example 62A were employed. Purification by HPLC [Method 7] gave 32 mg (70% of theory) of the title compound.

WORKUP

后处理

customPurification by HPLC [Method 7]

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d9b0abc1dabf471ebfc7b1f13d93afb3
来源数据集: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09034855B2
来源说明: uspto-grants-2015_05

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12](/[CH:13]=[CH:14]/[C:15]([F:18])([F:17])[F:16])[C:11](=[O:19])[N:10]([CH2:20][C:21]([OH:23])=O)[N:9]=2)=[CH:4][CH:3]=1.Cl.[NH2:25][CH:26]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[C:42]([F:45])([F:44])[F:43])[C:27]([NH:29][C:30]([CH3:35])([C:32]([NH2:34])=[O:33])[CH3:31])=[O:28]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12](/[CH:13]=[CH:14]/[C:15]([F:16])([F:17])[F:18])[C:11](=[O:19])[N:10]([CH2:20][C:21]([NH:25][CH:26]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=3[C:42]([F:43])([F:44])[F:45])[C:27]([NH:29][C:30]([CH3:35])([C:32]([NH2:34])=[O:33])[CH3:31])=[O:28])=[O:23])[N:9]=2)=[CH:6][CH:7]=1