Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-Cyclobutylpiperazine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Tert-butyl 4-cyclobutylpiperazine-1-carboxylate | HCID 57423951 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-Cyclobutylpiperazine hydrochloride | HCID 23090379 | 82% |
반응 단계
To the mixture of tert-butyl 4-cyclobutylpiperazine-1-carboxylate (48 g, 200 mmol) in MeOH (100 mL) was added 2.0 M HCl in MeOH (400 mL) carefully at 0° C. The mixture was stirred at rt for 5 h, concentrated under reduced pressure to afford the desired compound 1-cyclobutylpiperazine hydrochloride (35 g, 82%) [LCMS: Rt=0.94 min, m/z 141.3 (M+H)+].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09034874B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-0f9117a098e84406bf009e2d1faac3c8 |
| 출처 메모 | uspto-grants-2015_05 |