2-(Tributylstannyl)pyridine → HCID 6417974, compound

Participants

Reaction Conditions

Reaction Steps

The 6,6′-bis(pyridin-2-yl)-3,3′-bipyridazine 19 was prepared according to the general Stille coupling procedure, starting from a reaction mixture of 500 mg (4.42 mmol) of dichlorobipyridazine 17, 2.03 g (5.52 mmol) of 6-tributylstannylpyridine 18 and 387 mg (0.55 mmol) of dichlorobis(triphenylphosphine)-palladium(II), in 40 ml of DMF. The reaction mixture is heated at 95° C. for 24 h. The residue obtained is purified by silica gel chromatography (eluent: ethyl acetate/petroleum ether=1/9). The disubstituted product 19 is isolated with a yield of 62%.

Provenance & Evidence