HCID 59140934, compound → HCID 24944673, compound

Participants

Reaction Steps

The 3-(6-bromopyridin-2-yl)-6-(pyridin-2-yl)pyridazine was prepared according to the general Stille coupling method, starting from a mixture of 1.6 g (6.74 mmol) of 2,6-dibromobipyridine 42, 3 g (6.74 mmol) of 6-(pyridin-2-yl)-3-(tributylstannyl)pyridazine 39, 546 mg (0.47 mmol) of tetrakis(triphenylphosphine)-palladium(0) and 50 ml of freshly distilled toluene. The mixture is refluxed for 24 h. The residue obtained is chromatographed on a silica gel (eluent: ethyl acetate/petroleum ether=1/9). The brominated product 43 is isolated with a yield of 72%.

Provenance & Evidence