Triamcinolone Acetonide → Flurandrenolide

HRID 574196Notes

Reaction equation

[CH3:1][C@@:2]12[C@:10]3([C:16]([CH2:18][OH:19])=[O:17])[O:11][C:12]([CH3:15])([CH3:14])[O:13][C@@H:9]3[CH2:8][C@H:7]1[C@@H:6]1[CH2:20][CH2:21][C:22]3[C@@:28]([CH3:29])([C@@:5]1(F)[C@@H:4]([OH:31])[CH2:3]2)[CH:27]=[CH:26][C:24](=[O:25])[CH:23]=3.C[C@@]12[C@@](O)(C(CO)=O)[C@H](O)C[C@H]1[C@@H]1CCC3[C@@](C)([C@@]1([F:58])[C@@H](O)C2)C=CC(=O)C=3>>[CH3:29][C@@:28]12[C@H:5]3[C@@H:4]([OH:31])[CH2:3][C@:2]4([CH3:1])[C@:10]5([C:16]([CH2:18][OH:19])=[O:17])[O:11][C:12]([CH3:15])([CH3:14])[O:13][C@@H:9]5[CH2:8][C@H:7]4[C@@H:6]3[CH2:20][C@H:21]([F:58])[C:22]1=[CH:23][C:24](=[O:25])[CH2:26][CH2:27]2

Participants

Reactant 2

HCID 6436Triamcinolone Acetonide2×

HCID 31307Triamcinolone

Product 1

HCID 15209Flurandrenolide

Procedure

Triamcinolone acetonide 0.1% (Kenalog®, Aristocort® A ointment)

Sources & evidence

ORD record: ord-73cdfe78c58048eab4765400329290c4
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09034881B2

Reaction notes

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