HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-6-bromo-5-(trifluoromethyl)picolinohydrazide → 2-(5-(1,1,1-Trifluoro-2-(triisopropylsilyloxy)propan-2-yl)-1,3,4-oxadiazol-2-yl)-5-(trifluoromethyl)pyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-6-bromo-5-(trifluoromethyl)picolinohydrazide | HCID 86729595 | — |
| Reactant | 6-Bromo-2-(5-(1,1,1-trifluoro-2-(triisopropylsilyloxy)propan-2-yl)-1,3,4-oxadiazol-2-yl)-5-(trifluoromethyl)pyridin-3-amine | HCID 86729598 | — |
| Reactant | 3-Amino-5-(trifluoromethyl)picolinohydrazide | HCID 86729601 | — |
| Product | 2-(5-(1,1,1-Trifluoro-2-(triisopropylsilyloxy)propan-2-yl)-1,3,4-oxadiazol-2-yl)-5-(trifluoromethyl)pyridin-3-amine | HCID 86729600 | — |
Reaction Steps
The title compound was prepared analogously to 6-bromo-2-(5-(1,1,1-trifluoro-2-(triisopropylsilyloxy)propan-2-yl)-1,3,4-oxadiazol-2-yl)-5-(trifluoromethyl)pyridin-3-amine (Example 10, step 3) by replacing 3-amino-6-bromo-5-(trifluoromethyl)picolinohydrazide (Intermediate H) (step 1) with 3-amino-5-(trifluoromethyl)picolinohydrazide (Int. I); LCMS: Rt=1.66 min; [M+H]+ 499.3 Method 2minLC_v003.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034879B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-593c3fb0886543dda573bd6972f2a9cc |
| Source note | uspto-grants-2015_05 |