Trichloroisocyanuric Acid → HCID 71515812, compound

Participants

Reaction Steps

To (R)-2-(5-(3-amino-6-methoxy-5-(trifluoromethyl)pyridin-2-yl)-1,3,4-oxadiazol-2-yl)-1,1,1-trifluoropropan-2-ol (Example 2) (150 mg, 0.403 mmol) in acetonitrile (1 ml) was added trichloroisocyanuric acid (37.5 mg, 0.161 mmol) and the resulting mixture was heated using microwave radiation at 100° C. for 30 minutes followed by 125° C. for 10 minutes. The mixture was partitioned between EtOAc and water. The organic portion was separated and washed with sat.NaHCO3, brine, dried (MgSO4) and concentrated in vacuo. Purification of the crude product by chromatography on silica eluting with 0-30% EtOAc in iso-hexane afforded the title compound;

Provenance & Evidence