Carbamimidoyl-nitroso-acetic acid ethyl ester → HCID 12439913, compound

HRID 574237Notes

Reaction equation

HRID 574237 reaction equation
[CH2:1]([O:3][C:4](=[O:11])[CH:5]([C:8](=[NH:10])[NH2:9])[N:6]=O)[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:11])[CH:5]([NH2:6])[C:8](=[NH:9])[NH2:10])[CH3:2]

Participants

4

Reactant 1

HCID 12439904Carbamimidoyl-nitroso-acetic acid ethyl ester

Product 1

HCID 12439913HCID 12439913, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of carbamimidoyl-nitroso-acetic acid ethyl ester (5.5 g, 31.4 mmol) in ethanol/5M HCl (1:1 ratio, 250 ml) was added 10% Pd/C (1.3 g). The reaction mixture was hydrogenated (H2(g)) at low pressure over 2 nights. The Pd/C was filtered through Celite® (filter material) and the filtrate reduced in vacuo to give the title compound as a white solid. This was taken through to the next step as crude.

Workup

  1. customover 2 nights
  2. filtrationThe Pd/C was filtered through Celite® (filter material)

Sources & evidence

ORD record
ord-692c5bc03af24bc287b3e0e115f13cb5
Source dataset
uspto-grants-2015_05
Patent number
US09034879B2

Reaction notes

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