Methyl 3-amino-5-(trifluoromethyl)pyridine-2-carboxylate → 3-Amino-5-(trifluoromethyl)picolinohydrazide

HRID 574243Notes

Reaction equation

HRID 574243 reaction equation
[NH2:1][C:2]1[C:3]([C:13]([NH:15][NH2:16])=[O:14])=[N:4][C:5](Br)=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.COC(C1C(N)=CC(C(F)(F)F)=C(Br)N=1)=O.COC(C1C(N)=CC(C(F)(F)F)=CN=1)=O>>[NH2:1][C:2]1[C:3]([C:13]([NH:15][NH2:16])=[O:14])=[N:4][CH:5]=[C:6]([C:8]([F:10])([F:9])[F:11])[CH:7]=1

Participants

4

Reactant 3

HCID 58964419Methyl 3-amino-5-(trifluoromethyl)pyridine-2-carboxylate2×HCID 58964428Methyl 3-amino-6-bromo-5-(trifluoromethyl)picolinateHCID 867295953-Amino-6-bromo-5-(trifluoromethyl)picolinohydrazide

Product 1

HCID 867296013-Amino-5-(trifluoromethyl)picolinohydrazide

Procedure

The title compound was prepared analogously to Intermediate H by replacing 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (Intermediate A4) with 3-Amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (Intermediate A3);

Sources & evidence

ORD record
ord-664717366a1744a19873cba4726bcba1
Source dataset
uspto-grants-2015_05
Patent number
US09034879B2

Reaction notes

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