反应详情

A solution of 1-(2-fluoroethyl)-N-(3-methoxy-4-nitrophenyl)azetidin-3-amine (2.6 g) and Pd/C (1 g) in 1,4-dioxane (50 mL) was hydrogenated for 4 hours at room temperature. The reaction mixture was filtered through diatomaceous earth, washing with MeOH. The filtrate was concentrated and purified by column chromatography (DCM/MeOH=50/1 as elution) to provide the title compound (1.57 g, yield 68%, M+H+=240.2).

1. filtrationThe reaction mixture was filtered through diatomaceous earth
2. washwashing with MeOH
3. concentrationThe filtrate was concentrated
4. custompurified by column chromatography (DCM/MeOH=50/1 as elution)