反应详情

Compound 6a (3.87 g, 8.68 mmol) was dissolved in 40 ml of dichloromethane and 40 ml of trifluoroacetic acid was added. The mixture was stirred for overnight, at which time the solution was concentrated to dryness, dissolved in saturated NaHCO3 solution and extracted with EtOAc. The organic layer was dried over Na2SO4, filtered, and concentrated to yield 2.91 g (97%) of 7a as yellow wax, which was used in the next reaction. 1H NMR (400 MHz, CDCl3) 0.93-0.96 (t, 3H, J=12 Hz), 1.62 (m, 3H), 1.85-1.97 (m, 3H), 2.56 (m, 1H), 2.81-2.88 (m, 5H), 2.98-3.34 (m, 9H), 3.81 (s, 3H), 6.60 (s, 1H), 6.65-6.68 (d, 1H, J=12 Hz), 6.96-6.98 (d, 1H, J=8 Hz).

1. concentrationwas concentrated to dryness
2. dissolutiondissolved in saturated NaHCO3 solution
3. extractionextracted with EtOAc
4. dry with materialThe organic layer was dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated