Trifluoroacetic acid → HCID 45139976, compound

Participants

Reaction Steps

Compound 36a (5.1 g, 11.5 mmol) was dissolved in 40 ml of dichloromethane and 40 ml of trifluoroacetic acid was added. The mixture was stirred for 3 hr, at which time the solution was concentrated to dryness, dissolved in sat. NaHCO3, and extracted with EtOAc. The organic layer was dried (Na2SO4), filtered, and concentrated to yield 3.8 g (96%) of 37a, which was used as is in the next reaction. 1H NMR (400 MHz, CDCl3) 0.93-0.96 (t, 3H, J=7.6 Hz), 1.62 (m, 3H), 1.85-1.97 (m, 3H), 2.56 (m, 1H), 2.81-2.88 (m, 5H), 2.98-3.34 (m, 9H), 3.81 (s, 3H), 6.60-6.61 (dd, 1H, J=1.6 Hz), 6.65-6.78 (m, 1H), 6.95-6.98 (d, 1H, J=8.8 Hz).

Provenance & Evidence