Aluminium lithium hydride → HCID 67503454, compound

HRID 574300Notes

Reaction equation

HRID 574300 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH:7]([N:13]([CH2:23][CH2:24][CH3:25])[C:14](=O)[CH2:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)[CH2:8]2.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH:7]([N:13]([CH2:14][CH2:15][N:16]1[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1)[CH2:23][CH2:24][CH3:25])[CH2:8]2

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 67504275HCID 67504275, compound

Product 1

HCID 67503454HCID 67503454, compoundYield 91.8%

Procedure

This compound was prepared from 37b (4.8 g, 13.8 mmol) and LiAlH4 (2.0 g, 55.2 mmol) by following Procedure E to give 38b (4.2 g, 91%). 1H NMR (400 MHz, CDCl3) 0.92-0.96 (t, 3H, J=7.6 Hz), 1.41-1.59 (m, 3H), 1.98-2.22 (m, 1H), 2.41-3.1 (m, 19H), 3.81 (s, 3H), 5.2 (bs, 1H), 6.58-6.60 (d, 1H, J=8 Hz), 6.70-6.72 (d, 1H, J=8 Hz), 7.04-7.1 (t, 1H, J=8 Hz).

Sources & evidence

ORD record
ord-7ce00b5f398b4dd6946b593f8b08c327
Source dataset
uspto-grants-2015_05
Patent number
US09034877B2

Reaction notes

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