Indole-2-carboxaldehyde → HCID 45269785, compound

Participants

Reaction Steps

Compound 40d was prepared according to Procedure A using 39a (100 mg, 0.32 mmol) and 1H-Indole-2-carbaldehyde (100 mg, 0.69 mmol) to give 40d (125 mg, 85%) after column chromatography. 1H NMR (400 MHz, CDCl3) δ 0.86 (t, 3H, J=7.2 Hz), 1.39-1.50 (m, 3H), 1.89 (brs, 1H), 2.41-2.73 (m, 18H), 2.82-2.88 (m, 1H), 3.65 (s, 2H), 6.35 (s, 1H), 6.44 (brs, 1H), 6.54-6.57 (m, 1H), 6.87 (d, 1H, J=8.8 Hz), 7.04-7.08 (m, 1H), 7.10-7.16 (m, 1H), 7.30 (d, 1H, J=7.6 Hz), 7.54 (d, 1H, J=8.0 Hz), 8.63 (s, 1H). The free base of 40d was converted into oxalate salt. m.p. 135-137° C. Anal. [C28H38N4O.3.0(COOH)2.0.3H2O] C, H, N.

Provenance & Evidence