Indole-3-Carboxylic Acid → HCID 45273217, compound

Participants

Reaction Steps

Compound 10f was prepared following Procedure G using 39b (50 mg, 0.16 mmol) and indole-3-carboxylic acid (35 mg, 0.21 mmol) to give 40f (38 mg, 53%) after column chromatography. 1H NMR (400 MHz, CD3OD) δ 1.03-1.07 (t, 3H, J=7.2 Hz), 1.83-1.96 (m, 3H), 2.32 (s, 1H), 2.53-2.67 (m, 5H), 2.81-2.83 (m, 2H), 3.09-3.18 (m, 4H), 3.41-3.47 (m, 2H), 3.56-3.59 (m, 1H), 3.79 (bs, 4H), 6.61-6.63 (d, 1H, J=8.4 Hz), 6.64-6.66 (d, 1H, J=8.4 Hz), 6.96-6.99 (t, 1H, J=7.2 Hz), 7.13-7.21 (m, 1H), 7.41-7.51 (m, 1H), 7.62-7.64 (m, 1H), 7.71-7.73 (d, 1H, J=7.2 Hz), 7.83-7.84 (1H, J=7.2 Hz). The free base of 40f was converted into its HCl salt. m.p. 147-151° C. Anal. [C28H36N4O2.3HCl] C, H, N.

Provenance & Evidence