Benzofuran-2-carboxylic acid → HCID 45269797, compound

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Reaction Steps

Compound 40h was prepared following Procedure G using 39b (214 mg, 0.674 mmol) and benzofuran-2-carboxylic acid (131 mg, 0.809 mmol) to give 40h (108 mg, 35%) after column chromatography. 1H NMR (400 MHz, CD3OD) δ 0.94-0.98 (t, 3H, J=7.2 Hz), 1.60-1.68 (m, 3H), 2.14-2.65 (m, 8H), 2.77-3.03 (m, 8H), 3.87 (bs, 4H), 6.55-6.60 (m 2H), 6.89-6.93 (t, 1H, J=7.2 Hz), 7.29-7.33 (t, 1H, J=6.4 Hz), 7.36 (s, 1H), 7.42-7.45 (t, 1H, J=7.2 Hz), 7.56-7.58 (d, 1H, J=8.8 Hz), 7.70-7.72 (d, 1H, J=7.2 Hz). The free base of 40h was converted in to its HCl salt. m.p. decomp at 140° C. Anal. [C28H35N3O.2HCl.1.5H2O] C, H, N.

Provenance & Evidence