(R)-(-)-1-Indanol → HCID 71515784, compound

HRID 574642Notes

Reaction equation

HRID 574642 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH2:13][N:14]([C:17](=[O:19])[CH3:18])[CH2:15][CH2:16][C:11]=3[N:10]([C@H:20]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22][CH2:21]3)[N:9]=2)=[CH:4][CH:3]=1.[C@H]1(O)C2C(=CC=CC=2)CC1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH2:13][N:14]([C:17](=[O:19])[CH3:18])[CH2:15][CH2:16][C:11]=3[N:10]([C@@H:20]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22][CH2:21]3)[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6971243(R)-(-)-1-IndanolHCID 71515892HCID 71515892, compound

Product 1

HCID 71515784HCID 71515784, compound

Procedure

According to Scheme 7: In analogy to the synthesis of (12a), but taking (R)-1-indanol instead, 1-[(S)-3-(4-fluoro-phenyl)-1-indan-1-yl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone (12b) was obtained. Rt=2.46 min (LC method 6). Detected mass: 376.17 [M+H+].

Sources & evidence

ORD record
ord-28ddc057a458447488502b8ed772e629
Source dataset
uspto-grants-2015_05
Patent number
US09034897B2

Reaction notes

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