Hydrochloric Acid → HCID 89444490, compound

Participants

Reaction Conditions

Reaction Steps

According to Scheme 8: A mixture of (1R,2R)-4,6-difluoro-1-[3-(4-fluoro-phenyl)-5-isopropyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-indan-2-ol (11ae) (0.2 g, 0.468 mmol), ethanol (14 ml) and 2N aqueous HCl (14 ml) was stirred at 80° C. for 6h. The mixture was concentrated in vacuo. After addition of aqueous saturated NaHCO3, the mixture was extracted 3 times with ethyl acetate, solvents were evaporated in vacuo and the residue freeze-dried from CH3CN-water to give 0.170 g of (1R,2R)-4,6-difluoro-1-[3-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-indan-2-ol (13a).

Provenance & Evidence