Methyl chloroformate → HCID 71515726, compound

Participants

Reaction Conditions

Reaction Steps

According to Scheme 11: To a solution of 3-[1-((1R,2R)-4,6-difluoro-2-hydroxy-indan-1-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile (11t) (0.05 g, 0.123 mmol) in dry CH2Cl2 (2 ml) at 0° C. methyl chloroformate (12 mg, 0.13 mmol) and NEt3 (19 mg, 0.191 mmol) was added, the mixture was stirred at 0-5° C. for 60 min, then at 25° C. for 18 h. After addition of aqueous saturated NaHCO3 (2 ml), the mixture was extracted with CH2Cl2 (10 ml), the organic layer was dried over Na2SO4, solvents were evaporated in vacuo and the crude product was purified by purified by reverse phase HPLC (CH3CN/water gradient with 0.1% trifluoroacetic acid) to give 31 mg of 3-(3-cyano-phenyl)-1-((1R,2R)-4,6-difluoro-2-hydroxy-indan-1-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid methyl ester (17a).

Provenance & Evidence