HCID 131732846, compound → HCID 131732845, compound

HRID 574647Notes

Reaction equation

HRID 574647 reaction equation
[ClH:1].[CH:2]1([CH2:5][N:6]2[CH2:11][CH2:10][C:9]3[N:12]([C@@H:22]4[C:30]5[C:25](=[C:26]([F:32])[CH:27]=[C:28]([F:31])[CH:29]=5)[CH2:24][C@H:23]4[OH:33])[N:13]=[C:14]([C:15]4[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=4)[C:8]=3[CH2:7]2)[CH2:4][CH2:3]1>CC#N>[ClH:1].[CH:2]1([CH2:5][N:6]2[CH2:11][CH2:10][C:9]3[N:12]([CH:22]4[C:30]5[C:25](=[C:26]([F:32])[CH:27]=[C:28]([F:31])[CH:29]=5)[CH2:24][CH:23]4[OH:33])[N:13]=[C:14]([C:15]4[CH:16]=[CH:17][C:18]([F:21])=[CH:19][CH:20]=4)[C:8]=3[CH2:7]2)[CH2:3][CH2:4]1

Participants

3

Reactant 1

HCID 131732846HCID 131732846, compound

Product 1

HCID 131732845HCID 131732845, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The examples in the following table 8 were obtained according to Scheme 12 by following a reaction according to the synthesis of (18a). Sometimes, CH3CN was used instead of DMF and the temperature was decreased to 50° C.

Workup

  1. customwas decreased to 50° C.

Sources & evidence

ORD record
ord-628e7f99bcfb4559936681044e981d4b
Source dataset
uspto-grants-2015_05
Patent number
US09034897B2

Reaction notes

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