HCID 71515662, compound → HCID 71516118, compound

Participants

Reaction Conditions

Reaction Steps

According to Scheme 15: A mixture of 3-[5-acetyl-1-((1R,2R)-4-bromo-6-fluoro-2-hydroxy-indan-1-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile (11d) (0.15 g, 0.303 mmol) and CuCN (54 mg, 0.606 mmol) in dimethylsulfoxide (2 ml) was stirred at 180° C. for 90 min under microwave irradiation. The mixture was purified by reverse phase HPLC (CH3CN/water gradient with 0.1% trifluoroacetic acid) to give 27 mg of (1R,2R)-1-[5-acetyl-3-(3-cyano-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-6-fluoro-2-hydroxy-indan-4-carbonitrile (21b). Rt=1.16 min (LC method 4). Detected mass: 442.12 [M+H+].

Provenance & Evidence