Water → HCID 178524892, compound

Participants

Reaction Steps

To a solution of step G product (2-h, 0.7 g) in t-BuOH (35 mL) was added NaH2PO4.12H2O (0.6 g, 1.7 mmol) followed by H2O (6 mL) and NaClO2 (0.95 g, 10.5 mmol). After being allowed to stir at the ambient temperature overnight, the reaction mixture was evaporated under vacuum to remove t-BuOH, diluted with H2O, treated with aq. HCl to pH 2 and the solid was filtered and the cake was washed with water and dried under vacuum to afford compound 2-i as a crude (0.35 g), which was directly used for next step without further purification.

Provenance & Evidence