HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 178501651, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Glycine methyl ester hydrochloride | HCID 122755 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178491171 | HCID 178491171 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 178501651 | HCID 178501651 | — |
Reaction Steps
The mixture of compound 2-17-e (2.5 g, 6.1 mmol), methyl 2-aminoacetate hydrochloride (0.92 g, 7.3 mmol), TBTU (2.4 g, 7.3 mmol), DIPEA (1.6 g, 12.2 mmol) in DMSO (15 mL) and stirred at the ambient temperature overnight. Ice-water was then added to the reaction mixture and filtered. The cake was purified by column chromatography with DCM:MeOH=100:1˜50:1 to obtain the product, 2-17-f, (630 mg, 22%). LC-MS: (M+H)+ 481.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034851B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-eaf7856fc538404ebf132ac11e86d4d1 |
| Source note | uspto-grants-2015_05 |