HCID 178472777, compound → HCID 178525922, compound

Participants

Reaction Conditions

Reaction Steps

Compound 2-20 (300 mg, 0.67 mmol) was added to a 10% KOH solution (30 mL) and stirred at 50° C. for 30 min, then cooled to room temperature, washed with DCM (30 mL×2). The aqueous phase was acidified with 5% HCl to pH 23 and filtrated and dried to afford compound 2-21 as a white solid (200 mg, 79%). 1H NMR (300 MHz, DMSO-d6): δ 3.92-3.94 (d, J=6.0 Hz, 2H), 5.0-5.01 (d, J=3.0 Hz, 2H), 7.48-7.54 (m, 4H), 7.55-7.57 (m, 3H), 8.44 (br s, 1H), 9.40 (m, 1H), 9.93 (br s, 1H), 12.80 (br s, 1H), 13.56 (br s, 1H). LC-MS: (M−H)− 379.

Provenance & Evidence