反应详情

A mixture of compound 3-h (1 g, 3.0 mmol) in t-BuOH (20 mL) was added to a solution of NaH2PO4H2O (0.86 g, 2.4 mmol) in H2O (4 mL) and NaClO2 (0.8 g, 9 mmol). After being allowed to stir at room temperature for 3 h, the reaction mixture was added to aq. KOH (2M, 15 mL) and extracted with EA (30 mL). The aqueous layer was adjusted to pH=2 by addition of HCl, and then extracted with EA (30 mL) to afford the crude product, 3-1-a, (300 mg). LC-MS (M+H)+ 350.1

1. extractionextracted with EA (30 mL)
2. additionThe aqueous layer was adjusted to pH=2 by addition of HCl
3. extractionextracted with EA (30 mL)