Benzoic acid, 2-isothiocyanato-, methyl ester → 3-[3-(5-methyl-1H-imidazol-1-yl)propyl]-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one

HRID 574699Notes

Reaction equation

HRID 574699 reaction equation
[N:1]([C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[C:6]([O:8]C)=O)=[C:2]=[S:3].[CH3:14][C:15]1[N:19]([CH2:20][CH2:21][CH2:22][NH2:23])[CH:18]=[N:17][CH:16]=1>>[CH3:14][C:15]1[N:19]([CH2:20][CH2:21][CH2:22][N:23]2[C:6](=[O:8])[C:5]3[C:4](=[CH:13][CH:12]=[CH:11][CH:10]=3)[NH:1][C:2]2=[S:3])[CH:18]=[N:17][CH:16]=1

Participants

3

Reactant 2

HCID 85243Benzoic acid, 2-isothiocyanato-, methyl esterHCID 194294833-(5-methyl-1H-imidazol-1-yl)propan-1-amine

Product 1

HCID 250224083-[3-(5-methyl-1H-imidazol-1-yl)propyl]-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one

Procedure

The compound was synthesized starting from methyl 2-isothiocyanatobenzoate (0.276 g, 1.43 mmol) and 3-(5-methyl-1H-imidazol-1-yl)propan-1-amine (5) (0.198 g, 1.43 mmol) as described above.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-ad188edf22084762b9df61089a7b93a1
Source dataset
uspto-grants-2015_05
Patent number
US09034907B2

Reaction notes

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