Sulfuric Acid → HCID 67109353, compound

HRID 574738Notes

Reaction equation

HRID 574738 reaction equation
[C:1]1([CH3:12])[CH:6]=[CH:5][CH:4]=[C:3]([C@@H:7]([CH3:11])[C:8]([OH:10])=[O:9])[CH:2]=1.S(=O)(=O)(O)O.[C:18](=O)([O-])[O-].[Na+].[Na+]>CO>[C:1]1([CH3:12])[CH:6]=[CH:5][CH:4]=[C:3]([C@@H:7]([CH3:11])[C:8]([O:10][CH3:18])=[O:9])[CH:2]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 10340Sodium CarbonateHCID 67108859HCID 67108859, compound

Product 1

HCID 67109353HCID 67109353, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To (2R)-2-(m-tolyl)propionic acid (12.45 g) were added methanol (14.83 g) and concentrated sulfuric acid (6.46 g), and the mixture was stirred under refluxing for 6 hr. Then, the mixture was neutralized with 10% aqueous sodium carbonate solution, and extracted with hexane. After drying over magnesium sulfate, the residue was concentrated under reduced pressure to give the title compound (12.79 g). The structural property was as described below.

Workup

  1. temperatureunder refluxing for 6 hr
  2. extractionextracted with hexane
  3. dry with materialAfter drying over magnesium sulfate
  4. concentrationthe residue was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3d38f5a7aafc4dfdb1f6b8d26fa02524
Source dataset
uspto-grants-2015_05
Patent number
US09034906B2

Reaction notes

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