反应详情

温度

85 °C

To a solution of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The solution was stirred at 85° C. for 3 hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the pure title compound.

1. temperatureAfter cooling
2. filtrationthe solid was filtered off
3. distillationThe filtrate was subjected to vacuum distillation