HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-Boc-4,4-difluoro-L-proline methyl ester | HCID 11129200 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate | HCID 45082563 | — |
Reaction Steps
(S)-1-tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate (0.472 g) in CH2Cl2 (1 mL) was treated with trifluoroacetic acid (1.4 mL), stirred at ambient temperature for 4 hours, and concentrated. The product was free-based using a MEGA BE-SCX column with 1:1 CH2Cl2/methanol as eluent for the trifluoroacetic acid. The product was released from the column with 5% (7 M ammonia in methanol) in CH2Cl2 as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034875B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-1bb5d40599c04be0bbd0e56d737e3460 |
| Source note | uspto-grants-2015_05 |